I see no reason why you could not use it as often as you like, as long as you aren't allergic. Even multiple times a day. If you have a plant, cut off a small piece, slice it in half thin wise and rub it on your face. It is safe, soothing, moisturizing and natural. You can use it even on your most sensitive areas of your body, such as your crotch. It is very gentle. You may need to be more careful if you use bottled aloe vera gel, depending on what else is in it.